[Retracted] Ablation of Basic Leucine Zipper Transcription Factor ATF-Like Potentiates Estradiol to Induce Atopic Dermatitis

Figure 1

BATF-deficient female mice develop spontaneous atopic dermatitis. (a) A representative image of tails from 3 female BATF^–/– (Batf^–/–F) mice at 24–28 weeks of age and from one 26-week-old female WT (WT F) mouse. (b) Representative images of the facial and cervical skins from 24–28-week-old female BATF^–/– and WT mice. (c) Macroscopic scores of dermatitis in female BATF^–/– () and WT () mice at the indicated ages. Statistical significance was determined by two-way analysis of variance. (d) Representative H&E-stained tail skin sections from 28-week-old female BATF^–/– and WT mice. Scale bars: 200 μm (400× magnification) and 100 μm (200× magnification). (e) Epidermal thickness of the mouse tail skins was assessed by morphometric analysis. Data are shown as (SEM) of the epidermal thickness of the tail skins, with 10 mice per indicated group at 28 weeks of age.(f) Transepidermal water loss (TEWL) of the tail skins, with 22 mice per indicated group at 28 weeks of age. , , and , compared with the WT group.

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