[Retracted] Ablation of Basic Leucine Zipper Transcription Factor ATF-Like Potentiates Estradiol to Induce Atopic Dermatitis

Figure 2

Serum IgE levels and cytokine production in skin tissues are increased in female BATF^–/– mice. (a) A representative image of spleens and indicated lymph nodes from 20-week-old BATF^–/– and WT female mice. (b) Total serum IgE levels detected by enzyme-linked immunosorbent assay (ELISA) from 28-week-old female BATF^–/– and WT mice ( per group). (c) Dermal eosinophil, neutrophil, and lymphocyte counts per high-power field (HPF) in lesioned tail skins of 28-week-old female BATF^–/– and WT mice ( per group). (d) Decreased mRNA expression of filaggrin and loricrin combined with increased mRNA expression of S100 family proteins in the tail skin. (e) Relative mRNA expressions of IL-4, IL-5, IL-22, IL-1β, IFN-γ, and TNF-α in tail skins from 28-week-old female BATF^–/– and WT mice ( per group). Data are shown as (SD) and are representative of three independent experiments. , , and compared with the WT group.

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