<i>α</i>-Ketoglutarate Improves Meiotic Maturation of Porcine Oocytes and Promotes the Development of PA Embryos, Potentially by Reducing Oxidative Stress through the Nrf2 Pathway

<div>Proposed mechanism of the effect of <i>α</i>-KG supplementation during IVM on the developmental competence of pig embryos. <i>α</i>-KG can reduce oxidative stress and apoptosis and improve mitochondrial function in oocytes. The high quality and hatching rate of embryos developed from <i>α</i>-KG-treated oocytes could be accredited to the regulation of <i>Nrf2</i>/<i>ARE</i> signaling.</div>

Oxidative Medicine and Cellular Longevity

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Figure 10

Figure 10: <i>α</i>-Ketoglutarate Improves Meiotic Maturation of Porcine Oocytes and Promotes the Development of PA Embryos, Potentially by Reducing Oxidative Stress through the Nrf2 Pathway 

Figure 10 | α-Ketoglutarate Improves Meiotic Maturation of Porcine Oocytes and Promotes the Development of PA Embryos, Potentially by Reducing Oxidative Stress through the Nrf2 Pathway 