<i>α</i>-Ketoglutarate Improves Meiotic Maturation of Porcine Oocytes and Promotes the Development of PA Embryos, Potentially by Reducing Oxidative Stress through the Nrf2 Pathway

<div>Evaluation of treatments with <i>α</i>-KG and brusatol on porcine COCs and their competences in PA embryo development. (a) The effects of treatment with 20 <i>μ</i>M <i>α</i>-KG and 12 nM brusatol on CC expansion and subsequent embryonic development were evaluated. The four experimental groups (control group, brusatol group, <i>α</i>-KG group, and brusatol+<i>α</i>-KG group), COCs cumulus granulosa cell expansion bright field image, parthenogenetic activated embryo blastocyst bright field image, and Hoechst 33342 nuclear staining image. (b) Expansion of cumulus granulosa cells in each group of COCs. (c) Maturity rate of each group. (d) Cleavage rate of parthenogenetic embryos in each group. 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Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: <i>α</i>-Ketoglutarate Improves Meiotic Maturation of Porcine Oocytes and Promotes the Development of PA Embryos, Potentially by Reducing Oxidative Stress through the Nrf2 Pathway 

Figure 7 | α-Ketoglutarate Improves Meiotic Maturation of Porcine Oocytes and Promotes the Development of PA Embryos, Potentially by Reducing Oxidative Stress through the Nrf2 Pathway 