Exploration of the Protective Mechanism of Naringin in the Acetaminophen-Induced Hepatic Injury by Metabolomics

Figure 6

OSC-PLS-DA score plots (a–d) derived from the ¹H NMR spectra of liver and corresponding coefficient color-coded loading plots (e–h) obtained from different groups. The color map shows the significance of metabolite variations between the two classes. The color bar corresponds to the weight of the corresponding variable in the discrimination of statistically significant (red) or no significant (blue). Positive and negative peaks indicate a relatively decreased and increased metabolite level in different groups. Peaks in the positive direction indicate more abundant metabolites in the groups in the positive direction of the first principal component. Consequently, metabolites that are more abundant in the groups in the negative direction of the first primary component are presented as peaks in the negative direction. Keys to the assignments are shown in Figure 2(b). N:control; APAP; YL: APAP+low-dose therapy; YM: APAP+high-dose therapy.

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