Epigenome-Wide Association Study Reveals Differential Methylation Sites and Association of Gene Expression Regulation with Ischemic Moyamoya Disease in Adults

Figure 2

(a) The annotation results of all the different target genes were sorted according to the adjusted enrichment degree (. adjust) and the number of overlapping genes (count). (b) The KEGG database was used to show the pathways associated with differentially methylated genes, and the rankings were also based on . adjust and count. The size of the scatter represents the number of corresponding genes (count), and the closer the color is to red, the stronger is the significance (. adjust). (c) The target gene scatter-volcano map of differentially methylated gene loci; the blue dots on the upper left and the red dots on the upper right of the volcano map indicate that the changes in expression are more than 1 (, value <0.5), the downregulation and upregulation trends. Among them, there are 758 red dots and 256 blue dots. (d) The heat map shows all the different methylation sites in the 20 samples. The dark color denotes the hypermethylation site, and the light color denotes the hypomethylation site.

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