The Intestinal Redox System and Its Significance in Chemotherapy-Induced Intestinal Mucositis

Table 2

Subcellular location of oxidoreductases in intestine.

Enaymes name

Cytoplasm

Melanosome

Endosome

Endoplasmic reticulum

Mitochondrion

Peroxisome

Lysosome

Extracellular

Plasma membrane

Nucleus

Golgi

Cytoskeleton

Cell junction

NADPH oxidase

NOX1

√

NOX2

√

NOX3

NOX4

√

√

√

DUOX1

√

DUOX2

√

√

Xanthine dehydrogenase

√

√

√

Nitric oxide synthase

NOS1

√

NOS2

√

NOS3

√

√

√

Myeloperoxidase

√

Catalase

√

Superoxide dismutase

SOD1

√

√

√

SOD2

√

SOD3

√

√

Glutathione peroxidase

GPX1

√

√

GPX2

√

GPX3

√

GPX4

√

√

GPX5~7

√

GPX8

√

Peroxiredoxin

PRDX1

√

√

PRDX2

√

√

PRDX3

√

√

√

PRDX4

√

PRDX5

√

√

√

PRDX6

√

√

Heme oxygensae

HO-1

√

HO-2

√