Oxidative Medicine and Cellular Longevity

Review Article

The Intestinal Redox System and Its Significance in Chemotherapy-Induced Intestinal Mucositis

Table 4

Oxidoreductases and redox species in CIM.
5-FUMTXCPT-11CisplatinOxaliplatin
Oxidoreductases
 NADPH oxidase↑[297]
 Xanthine dehydrogenase↑[298]
 Nitric oxide synthase↑[240, 241, 250, 299]↑[300]
 Myeloperoxidase↑[241, 246, 257, 258, 299, 301–309]↑[269, 298, 310]↑[285, 297, 311–313]
 Catalase↓[239, 242, 247, 304, 314–316]↓[263, 310]↑[312]
 Superoxide dismutase↓[239, 242, 246, 247, 257, 304, 317]↓[263, 298, 310, 318]↓[285]↓[319, 320]↓[300]
 Glutathione peroxidase↓[242, 257, 310]↓[263, 310, 318]↓[285]↓[319, 320]
 Peroxiredoxin↓[265]
 Heme oxygenase↓[250] ↑[247]↓[285]
Redox species
 ROS↑[242, 243, 246, 250, 256, 321]↑[263, 298, 322, 323]↑[311, 312]
 Superoxides↑[246]
 Nitric oxide↑[247, 257]↑[285]↑[300]
 Hydrogen peroxide↑[302, 304]↑[324]
 Peroxynitrite↑
 Lipid peroxides↑[239, 241, 247, 257, 258, 301–304, 308, 314, 315, 317, 325, 326]↑[263, 269, 270, 310, 318]↑[285, 297, 311–313, 325]↑[319, 320, 327]↑[300]
 Nitrate↑[240, 308, 314]↑[273]↑[312]
 Protein carbonyls↑[239]↑[310]↑[327]
 GSH↓[242, 247, 257, 301, 303, 307, 314]↓[269, 270, 298]↓[297, 311–313, 325]↓[319, 320, 327]↓[300]