Epoxyeicosatrienoic Acids Inhibit the Activation of Murine Fibroblasts by Blocking the TGF-β1-Smad2/3 Signaling in a PPARγ-Dependent Manner

Figure 1

Inhibition of sEH attenuates the PF induced by BLM in mice. (a) TPPU (1 mg/kg/day, i.p.) was administered daily from the 7th day after BLM injection (1.5 mg/kg, i.t.). (b) Survival curves of mice (). (c) Bodyweight changes of mice (). (d) Lung sections of mice were analyzed by H&E staining. (e) The fibrotic area was expressed as a percentage of lung pathology (n =6). (f) The total protein concentration in BALF (n =6). (g) The LDH activity in BALF (n =6). , , and .

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