Hydrogen Sulfide Suppresses Skin Fibroblast Proliferation via Oxidative Stress Alleviation and Necroptosis Inhibition

Figure 2

NaHS inhibited keloid fibroblast migration after scratch. Skin fibroblasts were extracted from skin tissues of normal controls (normal skin) and scar tissue from patients with keloid (keloid), respectively. After pretreatment with NaHS (50 μM) or the same amount of culture medium (control) for 4 h, the fresh culture medium was replaced. The cells were scratched with a 10 μL pipette tip 12 h later. (a) Photos were taken after scratch for 0 h, 4 h, 8 h, 12 h, and 24 h. (b) The percentage of cell migration area to initial scratch area at different time. vs. normal skin + control; vs. keloid + control, .

(a)

(b)