Hydrogen Sulfide Suppresses Skin Fibroblast Proliferation via Oxidative Stress Alleviation and Necroptosis Inhibition

Figure 9

NaHS inhibited TGF-β₁-stimulated skin fibroblast migration after scratch. Skin fibroblasts were extracted from skin tissues of normal controls (normal skin). After pretreatment with NaHS (50 μM) for 4 h, skin fibroblasts were stimulated with TGF-β₁ (10 ng/mL) for 12 h. The cells were scratched with 10 μL pipette tip. (a) Photos were taken after scratch for 0 h, 4 h, 8 h, 12 h, and 24 h. (b) The percentage of cell migration area to initial scratch area at different time. vs. normal skin; vs. TGF-β₁, .

(a)

(b)