Reducing the Damage of Ox-LDL/LOX-1 Pathway to Vascular Endothelial Barrier Can Inhibit Atherosclerosis

Figure 1

The Transwell coincubation model confirmed that antibodies can reduce lipid deposition under endothelial cells and in the inner membrane. (a) Schematic diagram of the Transwell coincubation model. (b) Comparison of endothelial cells phagocytosing Dil-Ox-LDL under confocal laser irradiation in the control group and the antibody intervention group (100x). (c) Comparison of macrophages in the control group and the antibody intervention group phagocytosing Dil-Ox-LDL under confocal laser irradiation (40x). (d) Taking the fluorescence density of Dil-Ox-LDL phagocytosed by endothelial cells in the control group as baseline 1, the percentage of red fluorescence density of Dil-Ox-LDL phagocytosed by endothelial cells in the antibody intervention group. (e) Taking the fluorescence density of Dil-Ox-LDL phagocytosed by macrophages in the control group as the baseline 100%, the percentage of Dil-Ox-LDL phagocytosed by macrophages in the antibody intervention group. Values are expressed as . Student’s -test was applied for determining the significance of data. .

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