Interleukin-22 Deficiency Reduces Angiotensin II-Induced Aortic Dissection and Abdominal Aortic Aneurysm in ApoE-/- Mice

Figure 1

Effects of Ang II infusion for 4 weeks on IL-22 expression. (a and b). The aortic and serum IL-22 levels in the saline-infused group and Ang II-infused group were examined by western blotting and ELISA. (c). Aortic IL-22 expression was assessed by immunofluorescence analysis (200x). (d). Effect of Ang II treatment on the IL-22 mRNA expression in macrophages and CD4+ T lymphocytes. (e). Double staining with anti-F4/80 and anti-IL-22 antibodies and anti-CD4 and anti-IL-22 antibodies in Ang II-infused mice (200x). in each group. vs. the saline group.

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