MITD1 Deficiency Suppresses Clear Cell Renal Cell Carcinoma Growth and Migration by Inducing Ferroptosis through the TAZ/SLC7A11 Pathway

Figure 2

MITD1 knockdown inhibits ccRCC cell proliferation and migration. (a, b) 786-O cells or A498 cells were transfected with negative control or different si-RNA (SiMITD1-1 or SiMITD1-2). Western blot of MITD1 to test the effect of si-RNA transfection. (c, d) Knockdown of MITD1 suppressed cell growth ability in ccRCC cells (786-O and A498). (e) Proliferation of 786-O and A498 cells was suppressed by MITD1 knockdown. (f) When 786-O and A498 cells with different treatments grew to 90%-95% density, the surface of cells was scratched with a straight gap. Scratches at 0 and 24 hours were photographed and recorded under the microscope (magnification ×40;  μm). Values are expressed as the , .

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