MITD1 Deficiency Suppresses Clear Cell Renal Cell Carcinoma Growth and Migration by Inducing Ferroptosis through the TAZ/SLC7A11 Pathway

Figure 7

MITD1 knockdown suppresses growth and migration through the TAZ/SLC7A11 pathway. (a, b) 786-O cells or A498 cells were transfected with negative control or si-RNA for MITD1 (SiMITD1) and then were transfected with TAZ plasmid. Cell viability of each group was detected at 24 h, 48 h, 72 h, and 96 h, respectively. (c, d) Colony formation assay was performed on ccRCC cells with different treatments. The quantification data are also indicated. (e, f) When ccRCC cells with different treatments grew to 90%-95% density, the surface of cells was scratched with a straight gap. Scratches at 0 and 24 hours were photographed and recorded under the microscope (magnification ×40;  μm). The quantification data are also indicated. Values are expressed as the , . , relative to the control group; ^#, relative to the SiMITD1.

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