Ketone Body Improves Neurological Outcomes after Cardiac Arrest by Inhibiting Mitochondrial Fission in Rats

Figure 1

β-Hydroxybutyrate (β-HB) improved survival and neurological outcome after cardiac arrest. (a) The relative serum β-HB levels in rats at 6 h after return of spontaneous circulation (ROSC) (). (b) The relative brain β-HB levels in rats at 6 h after ROSC (). (c) β-HB treatment decreased serum lactate levels at 6 h after ROSC (). (d) Neurologic deficit scores of survived rats at 72 h after ROSC (). (e) Y-maze percent alternation of survived rats at 72 h after ROSC (). (f) β-HB treatment improved survival in rats within 72 h after ROSC (). Data are presented as . ^# versus control group. versus sham group.

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