Quantitative Crotonylome Analysis Reveals the Mechanism of Shenkang Injection on Diabetic Nephropathy

Figure 3

Differential crotonylation proteins and biological pathways identified to be regulated by Shenkang injection (SKI). (a) Cluster analysis of significantly changed Kcr proteins in db/m, db/db, and SKI-treated db/db mice groups according to their change tendencies (each fold line represents a protein). Proteins in clusters 1 and 3 were regarded as regulated by SKI. (b) Gene Ontology (GO) enrichment analysis of Kcr proteins regulated by SKI. (c) KEGG pathway enrichment analysis of Kcr proteins regulated by SKI. (d) Protein-protein interaction (PPI) network analysis for the Kcr proteins regulated by SKI based on the STRING database.

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