Ginkgolide C Alleviates Acute Lung Injury Caused by Paraquat Poisoning via Regulating the Nrf2 and NF-κB Signaling Pathways

Figure 5

Effects of GC on HO-1 expression and nuclear translocations of Nrf2 and NF-κB p65 in PQ-induced ALI rat model. (a1) GC obviously elevated the expression of HO-1. (b) GC obviously elevated the translocation of Nrf2 from cytosolic (b1) to nuclear (b2). (c) GC restrained the translocation of NF-κB p65 from cytosolic (c1) to nuclear (c2). The levels of Nrf2 and NF-κB p65 were separately determined in cytosolic and nuclear extracts. Results were expressed as Protein/reference protein ratio in each group (a2/b3/c3). Data were expressed as of three independent experiments. ^## vs. the control group; , vs. the PQ group.

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