Urocortin I Protects against Myocardial Ischemia/Reperfusion Injury by Sustaining Respiratory Function and Cardiolipin Content via Mitochondrial ATP-Sensitive Potassium Channel Opening

Figure 5

Cardiac functions after MIRI. After 40 min ischemia, rat hearts were subjected to MIRI. At the end of reperfusion, cardiac functions were evaluated by hemodynamic testing. (a) Changes of HR after MIRI ( in each group). , ^#, ^△, ^◇. (b) Changes of LVDP after MIRI ( in each group). , ^#, ^△, ^◇. (c) Changes of LVEDP after MIRI ( in each group). , ^#, ^△, ^◇. (d) Changes of dp/dt after MIRI ( in each group). , ^#, ^△, ^◇. (e) Hemodynamic data of isolated heart obtained from Langendorff device. MIRI: myocardial ischemia-reperfusion injury; HR: heart rate; LVDP: left ventricular development pressure; LVEDP: left ventricular end diastolic pressure; T₁: at the end of balance; T₂: at the end of reperfusion; : intragroup comparison with T₁; ^#: compared with N₁ group; ^△: compared with the IR group; ^◇: compared with the U₁ group.

(a)

(b)

(c)

(d)

(e)