Urocortin I Protects against Myocardial Ischemia/Reperfusion Injury by Sustaining Respiratory Function and Cardiolipin Content via Mitochondrial ATP-Sensitive Potassium Channel Opening

Figure 6

Mitochondrial respiratory function and respiratory enzymes activity after MIRI. After 40 min ischemia, rat hearts were subjected to MIRI. At the end of reperfusion, mitochondrial respiratory function and enzymes were determined by Lufthansa oxygen electrode. (a) Changes of RCR after MIRI ( in each group). , ^#, ^△, ^◇. (b) Changes of State3 after MIRI ( in each group). , ^#, ^△, ^◇. (c) changes of Suc-OX after MIRI ( in each group). , ^#, ^△, ^◇p < .05. (d) changes of NADH-OX after MIRI ( in each group). , ^#, ^△, ^◇. (e) Changes of Cytc-OX after MIRI ( in each group). , ^#, ^△, ^◇. MIRI: myocardial ischemia-reperfusion injury; RCR: respiratory control rate; NADH-OX: nicotinamide adenine dinucleotide phosphate oxidase; SUC-OX: succinate oxidase; Cytc-OX: cytochrome-c oxidase; T₁: at the end of balance, T₂: at the end of reperfusion; : intragroup comparison with T₁; ^#: compared with the N₁ group; ^△: compared with the IR group; ^◇: compared with the U₁ group.

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