Urocortin I Protects against Myocardial Ischemia/Reperfusion Injury by Sustaining Respiratory Function and Cardiolipin Content via Mitochondrial ATP-Sensitive Potassium Channel Opening

Figure 8

Relative changes of indexes on cellular level after HRI. After 40 min anoxia, cardiomyocytes were subjected to HRI. At the end of reoxygenation, change of mPTP, MMP, and ROS generation was determined by fluorimetry. (a) Relative change of mPTP activity ( in each group). , ^##, ^△△. (b) Relative decrease of MMP ( in each group). , ^#, ^△. (c) Relative generation of ROS ( in each group). , ^##, ^△△. HRI: hypoxia reoxygenation injury; mPTP: mitochondrial permeable transition pore; MMP: mitochondrial membrane potential; ROS: reactive oxygen species; : compared with the N₂ group; ^#: compared with the HR group; ^△: compared with the U₂ group.

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