Sesamol Attenuates Neuroinflammation by Regulating the AMPK/SIRT1/NF-κB Signaling Pathway after Spinal Cord Injury in Mice

Figure 7

Sesamol regulates the AMPK/SIRT1/NF-κB pathway in BV2 cells suffering from LPS. (a) Western blot images showing that compound C reversed p-AMPK, AMPK, SIRT1, p-p65, and p65 protein expression regulated by sesamol in BV2 cells incubated with LPS. (b–d) Quantification of p-AMPK/AMPK ratio, SIRT1, and p-p65/p65 ratio data from (a) ( per group). (e) Representative images showing that compound C counteracted fluorescence intensity of SIRT1 (green) increased by sesamol (). (f) Representative images showing that sesamol decreased fluorescence intensity of nuclear p65 (red) while it was reversed by compound C (). (g, h) Quantification of the fluorescence degree of SIRT1 and p65 in BV2 from (e) and (f), respectively ( per group). Results are represented as the . ^#, ^##, ^###, and ^####.

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