Clinical Significance of Albumin- and Bilirubin-Based Biomarkers in Glaucoma: A Retrospective Case-Control Study

Figure 1

Associations of serum ALB, BIL, NAR, NTBR, and NIBR with disease severity. Serum levels of (a) ALB, (b) TBIL, (c) IBIL, (d) NAR, (e) NTBR, and (f) NIBR among different glaucoma patient groups stratified according to disease severity. The severity of glaucoma was determined based on the mean deviation (MD) of visual field: early () indicates visual field MD of greater than -6 dB; moderate (), -12 dB to -6 dB; and severe (), no greater than -12 dB. Kolmogorov-Smirnov test was performed for checking data normality. The differences of all parameters among three groups were first examined by Kruskal-Wallis test, followed by Dunn’s multiple comparisons test to determine the differences of each group with every other group (adjusted values are shown). , , , and . HC: healthy controls; ALB: albumin; TBIL: total bilirubin; IBIL: indirect bilirubin; NAR: neutrophil-to-albumin ratio; NTBR: neutrophil-to-total bilirubin ratio; NIBR: neutrophil-to-indirect bilirubin ratio.

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