Clinical Significance of Albumin- and Bilirubin-Based Biomarkers in Glaucoma: A Retrospective Case-Control Study

Table 4

The discriminative abilities of variables in patients with glaucoma, stratified according to disease severity.

	Early vs. moderate			Early vs. severe			Moderate vs. severe
	AUC		Max. Youden	AUC		Max. Youden	AUC		Max. Youden
ALB	0.5356	0.5377	0.09	0.6096	0.0553	0.21	0.6353	0.0069	0.22
IBIL	0.5899	0.1203	0.27	0.6345	0.0187	0.30	0.5190	0.7051	0.13
NAR	0.6672	0.0039	0.30	0.7554	<0.0001	0.46	0.6040	0.0378	0.25
NTBR	0.6713	0.0031	0.34	0.7027	0.0004	0.36	0.5177	0.7234	0.08
NIBR	0.6934	0.0008	0.35	0.7250	<0.0001	0.40	0.5153	0.7604	0.08

The severity of glaucoma was determined based on the mean deviation (MD) of visual field: early indicates visual field MD of greater than -6 dB; moderate, -12 dB to -6 dB; and severe, no greater than -12 dB. Receiver operating characteristic (ROC) curve analysis was performed. Youden index was calculated as . was considered statistically significant.