N-((1-(4-Fluorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-2-methylene-3-oxo-olean-12-en-28-amide Induces Apoptosis in Human Breast Cancer Cells by Stimulating Oxidative Stress and Inhibiting the Notch-Akt Signaling Pathway

<div>ZQL-4c significantly inhibited the growth of breast cancer cells. (a)–(c) MCF-7, MDA-MB-231, and SK-BR-3 cells were treated with various concentrations of ZQL-4c for increasing times. Line graphs showed the percentage of viable MCF-7, MDA-MB-231, and SK-BR-3 cells after treatment with 0, 0.4, 0.8, 1.0, 2.0, 4.0, and 8.0 <i>μ</i>mol/L ZQL-4c for 24 and 48 h, as determined by the CCK8 assay. 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(d) Histogram showing the IC<sub>50</sub> values (24 h and 48 h) of ZQL-4c in MCF-7, MDA-MB-231, and SK-BR-3 cells.</div>

Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: N-((1-(4-Fluorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-2-methylene-3-oxo-olean-12-en-28-amide Induces Apoptosis in Human Breast Cancer Cells by Stimulating Oxidative Stress and Inhibiting the Notch-Akt Signaling Pathway 

Figure 2 | N-((1-(4-Fluorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-2-methylene-3-oxo-olean-12-en-28-amide Induces Apoptosis in Human Breast Cancer Cells by Stimulating Oxidative Stress and Inhibiting the Notch-Akt Signaling Pathway 