N-((1-(4-Fluorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-2-methylene-3-oxo-olean-12-en-28-amide Induces Apoptosis in Human Breast Cancer Cells by Stimulating Oxidative Stress and Inhibiting the Notch-Akt Signaling Pathway

<div>ZQL-4c suppresses Notch-Akt signaling pathways in breast cancer cells. MCF-7, MDA-MB-231, and SK-BR-3 cells were treated with 0, 0.4, 0.8, and 1.6 <i>μ</i>mol/L ZQL-4c for 24 h. (a)–(c) The protein levels of Notch1, Notch2, mTOR, phospho-mTOR, AKT, phospho-AKT, JAK2, phospho-JAK2, STAT3, and phospho-STAT3 were detected by western blotting. Actin was used as a loading control.</div>

Oxidative Medicine and Cellular Longevity

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Figure 7

Figure 7: N-((1-(4-Fluorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-2-methylene-3-oxo-olean-12-en-28-amide Induces Apoptosis in Human Breast Cancer Cells by Stimulating Oxidative Stress and Inhibiting the Notch-Akt Signaling Pathway 

Figure 7 | N-((1-(4-Fluorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-2-methylene-3-oxo-olean-12-en-28-amide Induces Apoptosis in Human Breast Cancer Cells by Stimulating Oxidative Stress and Inhibiting the Notch-Akt Signaling Pathway 