HNF4A Regulates the Proliferation and Tumor Formation of Cervical Cancer Cells through the Wnt/β-Catenin Pathway

Figure 6

HNF4A suppressed the Wnt/β-catenin pathway in a mouse xenograft. (a) Expression of HNF4A, β-catenin, c-Myc, and cyclin D1 in tumor xenografts derived from HeLa-GFP cells and HeLa-HNF4A cells. (b) Immunoreactivity scores of HNF4A, β-catenin, c-Myc, and cyclin D1 in xenograft tissues derived from HeLa-GFP cells and HeLa-HNF4A cells. (c) Expression of HNF4A, β-catenin, c-Myc, and cyclin D1 in xenografts derived from SiHa-GFP and SiHa-HNF4A cells. (d) Immunoreactivity scores of HNF4A, β-catenin, c-Myc, and cyclin D1 in xenograft tissues derived from SiHa-GFP cells and SiHa-HNF4A cells. Representative images were shown. Scale bar: 10 μm. Data represent of triplicate experiments, and statistical analysis was done by Student’s -test. , .

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