Apigenin Induced Apoptosis by Downregulating Sulfiredoxin Expression in Cutaneous Squamous Cell Carcinoma

Figure 6

The summarization of the effect of apigenin in cSCC cell lines. After treatment with apigenin, the MAPK signaling pathway was activated gradually through the form of phosphorylation, especially the ERK1/2 pathway. Then, Phospho-MAPK from the cytoplasm to nucleus may generally downregulate the expression of Srx by inhibiting the expression of Nrf2. Then, apigenin might induce cell apoptosis in cSCC cells.