Intrinsic ROS Drive Hair Follicle Cycle Progression by Modulating DNA Damage and Repair and Subsequently Hair Follicle Apoptosis and Macrophage Polarization

Figure 11

Cas 3 inhibition delayed regress of HFs, while PARP1 inhibition promoted degeneration of HFs. (a, c) There is no difference in the weight of the mice among various groups. (b, d–f) HE staining showed an increase in thickness of dorsal skin and HF density in mice treated with Ac compared to controls. Diameter of hair bulbs in mice treated with BMN 673 was decreased, while it increased in mice treated with Ac. Data of HF density are presented as of number of HFs under 100x lens: control: , Ac: , BMN 673: , and Ac+B: . , , , and . Scale bar (b): 200 μm.

(a)

(b)

(c)

(d)

(e)

(f)