Intrinsic ROS Drive Hair Follicle Cycle Progression by Modulating DNA Damage and Repair and Subsequently Hair Follicle Apoptosis and Macrophage Polarization

Figure 13

Cas 3 inhibitor reduced the activity of Cas 3 but upregulated 57 kDa AIF in HF cells, whereas the PARP1 inhibitor reduced the expression of 57 kDa AIF but promoted Cas 3 activity. (a, b) Immunofluorescence staining showed that MFI of 57 kDa AIF was increased in the hair follicle in mice treated with Ac, while it was decreased in mice treated with BMN 673. (c, d) Immunofluorescence staining showed that MFI of c-Cas 3 was decreased in the hair follicle in mice treated with Ac, while it was increased in mice treated with BMN 673. , . Scale bar (a, c): 100 μm.

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