Intrinsic ROS Drive Hair Follicle Cycle Progression by Modulating DNA Damage and Repair and Subsequently Hair Follicle Apoptosis and Macrophage Polarization

Figure 3

Apoptosis was involved in regulating the hair cycle. (a–h) Western blot () showed that capacity of PARP1 was enhanced in catagen that expressions of 116 kDa PARP1 and PAR were increased. The level of 89 kDa PARP1 was increased in catagen, and more AIF translocated from mitochondria to the nucleus in HFs in catagen. Cas 3 was activated in the hair follicle during the whole hair cycle, while c-Cas 3 was downregulated in early catagen with Cyto c. , , , and .

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