Intrinsic ROS Drive Hair Follicle Cycle Progression by Modulating DNA Damage and Repair and Subsequently Hair Follicle Apoptosis and Macrophage Polarization

Figure 5

DNA repair was involved in regulating the hair cycle. (a–h) Western blot showed that expression of γH2AX was increased in catagen. DNA damage repair proteins of HR and NHEJ pathways, p-ATM, p-BRCA 1, Rad51, KU80, and KU70, were upregulated in early catagen, while the DNA damage repair protein of the BER pathway—OGG1—was decreased during catagen and telogen. (i, j) Concentrations of NAD+ and NADH in HFs were decreased in catagen and telogen. , , , and .

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