Intrinsic ROS Drive Hair Follicle Cycle Progression by Modulating DNA Damage and Repair and Subsequently Hair Follicle Apoptosis and Macrophage Polarization

Figure 9

Cas 3 inhibition delayed the degeneration of hair follicles (HFs). (a) Gross observation of mice treated with Ac. (b, d) HE staining of the dorsal skin showed that skin thicknesses were increased in mice treated with 4 and 8 mg/kg Ac. (c) The weight of mice had no significant changes in mice treated with Ac. (e, f) HF density and diameters of hair bulbs were increased in mice treated with 8 mg/kg Ac. Data of HF density are presented as of number of HFs under 100x lens: control: , Ac 2 mg/kg: , Ac 4 mg/kg: , and Ac 8 mg/kg: . , , and . Scale bar (b): 200 μm.

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