Ageing Increases Cardiac Electrical Remodelling in Rats and Mice via NOX4/ROS/CaMKII-Mediated Calcium Signalling

Figure 2

ISO increased cardiac arrhythmias incidence in old mice in vivo. (a) The typical ECG recording showing that ageing increased susceptibility to ISO-induced arrhythmias using PES with PCL from 90 ms to 30 ms. (b) Histogram of the VT occurrence rate in young and old mice with or without treatment of ISO (1 mg/kg, i.p.) ( and ).

(a)

(b)