Research Article

Ageing Increases Cardiac Electrical Remodelling in Rats and Mice via NOX4/ROS/CaMKII-Mediated Calcium Signalling

Figure 7

Schematic image of the signalling pathways of ageing-induced arrhythmias. Ageing increases the susceptibility to ventricular arrhythmias through NOX4/ROS/CaMKII pathway-mediated cardiac remodelling and abnormal coupling.