lncRNA SNHG15 Induced by SOX12 Promotes the Tumorigenic Properties and Chemoresistance in Cervical Cancer via the miR-4735-3p/HIF1a Pathway

Figure 2

lncRNA SNHG15 knockdown attenuates cervical cancer (CC) tumorigenesis and chemoresistance in vitro. (a) lncRNA SNHG15 expression in CC cells after knockdown with two siRNAs, measured by qRT-PCR. (b, c) Cell proliferation in (b) SiHa and (c) HeLa cells, detected using the MTT assay. (d, e) Cell viabilities in (d) SiHa and HeLa cells, evaluated using the EdU assay; (e) analysis of results. (f) Cell apoptosis measured by flow cytometry assay and (g) calculation of the results. (h) Cell migration, assessed using the transwell migration experiment; (i) statistical analysis. (j) SiHa and (k) HeLa cells were treated with cisplatin at varying concentrations; chemoresistance of CC cells was evaluated using the MTT assay. Data are presented as ; and .

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