lncRNA SNHG15 Induced by SOX12 Promotes the Tumorigenic Properties and Chemoresistance in Cervical Cancer via the miR-4735-3p/HIF1a Pathway

Figure 5

miR-4735-3p modulates tumorigenesis and chemoresistance in cervical cancer. (a) The gain- or loss-of-function of miR-4735-3p cell models was generated as indicated. (b–d) Cell proliferation of SiHa and HeLa cells upon miR-4735-3p dysregulation, detected using the MTT assay. (f, g) Cell proliferation levels of SiHa and HeLa cells upon miR-4735-3p (f) overexpression or (g) downregulation, evaluated using the EdU assay. (h, i) Cell apoptosis of SiHa and HeLa cells upon miR-4735-3p (h) overexpression or (i) downregulation, measured by flow cytometry. (j, k) Cell migration levels of SiHa and HeLa cells upon miR-4735-3p (j) overexpression or (k) downregulation, assessed using the transwell migration assay. (l–o) Chemoresistance of SiHa and HeLa cells upon miR-4735-3p dysregulation, detected using the MTT assay. Data are presented as , ; ; .

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