Electroacupuncture Enhances Neuroplasticity by Regulating the Orexin A-Mediated cAMP/PKA/CREB Signaling Pathway in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice

Figure 3

EA at 10 Hz rescues spatial learning and memory impairment in SAMP8 mice. (a) The histogram shows the average latency of the mice to reach the hidden platform on the 5 consecutive training days. (b) The histogram shows the percentage of time the mice spent in the target quadrant during the probe test. (c) The histogram shows the number of hidden platform location crossings. (d, e) Representative swimming tracks of the mice in the test phase on day 5 of the test and the probe test on day 6. The large circle represents the water maze, and the small circle represents the platform. (f) There was no significant difference in the average swimming speed among the four groups of mice over a 5-day period (; compared with the control group, and ; compared with the model group, and ; ns: not significant).

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