Early Development of Cardiac Fibrosis in Young Old-Father Offspring

Figure 7

Effect of older paternal age at conception on the exacerbation of cardiac remodeling and development of myocardial fibrosis in the young rat progeny, through activation of the TGF-β signaling pathway, particularly in the case of chronic circulatory stress. The early development of cardiac remodeling associated with paternal age in the young progeny appears to be transmitted intergenerationally. Clinically, the early onset of heart failure in young hypertensive offspring may be correlated with advanced paternal age during conception.