Research Article

Identification of Prognostic DNA Methylation Signatures in Lung Adenocarcinoma

Figure 2

Multiomic characteristics of 20 DNA methylation-related genes in the TCGA-LUAD data set. (a) The mutation of 20 DNA methylation-related genes in LUAD and the overall mutation rate of DNA methylation-related genes in varying degrees in the genome. (b) The copy number variation of DNA methylation-related genes was counted and dominated by copy number variation. (c) At the transcriptome level, DNMT1, DNMT3A, DNMT3B, TET1, TET2, TET3, MBD1, MBD4, ZBTB33, UHRF1, UHRF2, UNG, TDG, NTHL1, and SMUG1 were significantly overexpressed in tumor tissues, while ZBTB4 was significantly downregulated in tumor tissues. (d) There were certain interactions between genes at the protein level.
(a)
(b)
(c)
(d)