Identification of Prognostic DNA Methylation Signatures in Lung Adenocarcinoma

Figure 6

Identification and characteristic analysis of differential gene subtypes. (a) The role of 1396 differentially expressed genes in the grouping of differential gene subtypes is shown by heatmap; (b) cluster 1 group had prolonged survival time. (c) In line with the characteristics of immune cell infiltration and immune signatures, many stimulatory immunomodulators or immune checkpoint molecules were generally unregulated in DNA methylation regulator cluster 1; (d–f) the difference in DNA methylation score (DMS) between high and low groups of tumor mutation load (TMB), between DNA methylation subtypes, and between different gene subtypes (deg. cluster).

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