BMSC-EV-derived lncRNA NORAD Facilitates Migration, Invasion, and Angiogenesis in Osteosarcoma Cells by Regulating CREBBP <i>via</i> Delivery of miR-877-3p

<div>BMSC-EVs facilitated OS cell proliferation, invasion, migration, and angiogenesis. (a) Expression of NORAD in hFOB 1.19, 143B, MG63, Saos2, HOS, and U-2OS cells detected by RT-qPCR; (b) internalization of PKH-labeled EVs by OS cells detected by immunofluorescence; (c) effect of EVs on OS cell proliferation detected by CCK-8; (d) effect of EVs on OS cell invasion detected by the Transwell assay; (e) effect of EVs on OS cell migration detected by the Transwell assay; (f) effect of EVs on OS cell tube formation detected by tube formation assay. Cell experiment was repeated 3 times. 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547C213 587 217 598 226 604C236 612 262 617 304 617C371 617 429 604 474 576C554 529 592 439 592 336C592 176 505 36 319 36C246 36 213 55 213 131V547Z"></path></g></svg>.</span> One-way ANOVA was used for comparisons among multigroups, and Tukey’s multiple comparisons test was applied for a post hoc test. <span class="nowrap"><svg height="13.532pt" id="M40" style="vertical-align:-3.4295pt" version="1.1" viewbox="-0.0498162 -10.1025 50.6052 13.532" width="50.6052pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: BMSC-EV-derived lncRNA NORAD Facilitates Migration, Invasion, and Angiogenesis in Osteosarcoma Cells by Regulating CREBBP <i>via</i> Delivery of miR-877-3p 

Figure 2 | BMSC-EV-derived lncRNA NORAD Facilitates Migration, Invasion, and Angiogenesis in Osteosarcoma Cells by Regulating CREBBP via Delivery of miR-877-3p 