BMSC-EV-derived lncRNA NORAD Facilitates Migration, Invasion, and Angiogenesis in Osteosarcoma Cells by Regulating CREBBP via Delivery of miR-877-3p

Figure 3

BMSC-EVs promoted OS cell proliferation, invasion, migration, and angiogenesis by carrying NORAD. (a) Effect of EVs on NORAD expression in OS cells detected by RT-qPCR; (b) expression of NORAD in EVs detected by RT-qPCR; (c) expression of NORAD in EVs and OS cells detected by RT-qPCR; (d) expression of NORAD in BMSCs and EVs after silencing NORAD detected by RT-qPCR; (e) expression of NORAD in OS cells detected by RT-qPCR; (f) OS cell proliferation detected by CCK-8; (g) OS cell invasion detected by the Transwell assay; (h) OS cell migration detected by the Transwell assay; (i) OS cell tube formation detected by tube formation assay. Cell experiment was repeated 3 times. Data were presented in the form of . The independent-sample test was used for pairwise comparisons, one-way ANOVA for comparisons among multigroups, and Tukey’s multiple comparisons test was used for a post hoc test. , , .

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