Methylglyoxal Scavengers Attenuate Angiogenesis Dysfunction Induced by Methylglyoxal and Oxygen-Glucose Deprivation

<div>NAC or AG can protect against the inhibitory effect of MG observed in chorioallantoic membrane (CAM) assay. (a–d, a1–d1) Representative bright-field images of chicken embryo CAM vascular plexus were taken from the control, 2 mmol/L MG, MG+AG, and MG+NAC groups. (a2–d2) The representative H&amp;E-stained cross sections of the parts indicated by the lines in (a1)–(d1), respectively. DAPI (a3–d3), Cav1 (a4–d4), and merged (a5–d5) immunofluorescence staining shows the cross section of the part indicated by the line in (a1)–(d1). (e) The density of vascular plexus on chicken embryo CAM. (f) A comparison of chick embryo CAM vessel diameter. 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550Z"></path></g></svg> mm in (a)–(d); 2 mm in (a1)–(d1); 100 <i>μ</i>m in (a2)–(d5).</div>

Oxidative Medicine and Cellular Longevity

fig8

Figure 8

Figure 8: Methylglyoxal Scavengers Attenuate Angiogenesis Dysfunction Induced by Methylglyoxal and Oxygen-Glucose Deprivation 