Cell-Dependent Pathogenic Roles of Filamin B in Different Skeletal Malformations

Figure 3

Protein structure prediction of wild-type and mutant FLNB repeat 15 and 22 and sequence alignments of mutated region. (a) Protein structure prediction of wild-type repeat 15. (b) Protein structure prediction of T1616A repeat 15. (c) Protein structure prediction of wild-type repeat 22. (d) Protein structure prediction of I2341R repeat 22. (e) Conservation analysis of T1616A variant via multiple sequence alignment. Changed amino acids are marked in red. (f) Conservation analysis of I2341R variant via multiple sequence alignment. Changed amino acids are marked in red.

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