α-Lipoic Acid-Plus Ameliorates Endothelial Injury by Inhibiting the Apoptosis Pathway Mediated by Intralysosomal Cathepsins in an In Vivo and In Vitro Endothelial Injury Model

<div>Structure of DFO, LAP, and DHLAP and experimental design. (a) Structure of DFO. (b) Structure of LAP and DHLAP. (c) Experiment 1 was designed to determine the involvement of cathepsin B/D under CAII conditions. (d) Experiment 2 was designed to explore the mechanisms of LAP in alleviating endothelial injury induced by CAII. (e) Experiment 3 was designed to explore the role and mechanisms of LAP in alleviating HUVEC injury induced by OxyHb in vitro.</div>

Oxidative Medicine and Cellular Longevity

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Figure 1

Figure 1: α-Lipoic Acid-Plus Ameliorates Endothelial Injury by Inhibiting the Apoptosis Pathway Mediated by Intralysosomal Cathepsins in an In Vivo and In Vitro Endothelial Injury Model

Figure 1 | α-Lipoic Acid-Plus Ameliorates Endothelial Injury by Inhibiting the Apoptosis Pathway Mediated by Intralysosomal Cathepsins in an In Vivo and In Vitro Endothelial Injury Model 