α-Lipoic Acid-Plus Ameliorates Endothelial Injury by Inhibiting the Apoptosis Pathway Mediated by Intralysosomal Cathepsins in an In Vivo and In Vitro Endothelial Injury Model

<div>Effect of DFO and LAP treatments on lysosomal integrity following HUVEC injury. (a) IF analysis was performed using LAMP-1 antibody (green), and the nuclei were fluorescently labeled with DAPI (blue). (b) Lyso-Tracker Red cellular staining: red staining indicates intact lysosomes in HUVECs. (c) AO staining: orange staining indicates acidic compartment accumulation in HUVECs. Scale bar, 100 μm.</div>

Oxidative Medicine and Cellular Longevity

fig9

Figure 9

Figure 9: α-Lipoic Acid-Plus Ameliorates Endothelial Injury by Inhibiting the Apoptosis Pathway Mediated by Intralysosomal Cathepsins in an In Vivo and In Vitro Endothelial Injury Model

Figure 9 | α-Lipoic Acid-Plus Ameliorates Endothelial Injury by Inhibiting the Apoptosis Pathway Mediated by Intralysosomal Cathepsins in an In Vivo and In Vitro Endothelial Injury Model 