Beta-caryophyllene as an antioxidant, anti-inflammatory and re-epithelialization activities in a rat skin wound excision model

Table 1

Systemic toxicity analysis data for liver (AST, ALT, γ-GT) and renal (creatinine, urea) parameters in the serum of rats treated for 14 days.

Groups	AST (IU/L)	ALT (IU/L)	γ-GT (IU/L)	Creatinine (mg/dL)	Urea (mg/dL)
FST	143 ± 28	62 ± 12	1.2 ± 0.4	0.30 ± 0.03	44 ± 2.1
NeBa	138 ± 17	65 ± 7.7	1.1 ± 0.3	0.31 ± 0.04	44 ± 6.2
Dex	150 ± 28	80 ± 17	0.9 ± 0.3	0.27 ± 0.03	43 ± 5.6
Col	153 ± 29	63 ± 12	1.0 ± 0.2	0.30 ± 0.05	45 ± 4.6
Emulgel	146 ± 6.1	65 ± 8.5	1.1 ± 0.2	0.26 ± 0.04	44 ± 4.7
Car	124 ± 14	60 ± 9.5	1.1 ± 0.2	0.31 ± 0.03	42 ± 7.6
Control	147 ±25	65 ± 9.1	1.0 ± 0.2	0.30 ± 0.02	44 ± 4.9

One-way ANOVA followed by Tukey test, with p ≤0.05 (n =5). FST: wounded animal without treatment; NeBa: wounded animal treated with neomycin 5 mg/g + sulfate bacitracin zinc 250 IU/g; Dex: wounded animals treated with dexpanthenol 5%; Col: wounded animals treated with collagenase 1.2 IU; Emulgel: wounded animals treated with emulgel (vehicle); Car: wounded animals treated with β-caryophyllene emulsion; Control: animals without lesion and treatment – physiologic pattern.