Molecular Correlates of Early Onset of Diabetic Cardiomyopathy: Possible Therapeutic Targets

Figure 3

RNA-Seq analysis revealed differentially expressed genes (DEGs) in the left ventricle from control, low, and high doses of streptozotocin-injected high-fat diet rats. (a) The bar graph shows the number of up and downregulated DEGs in Con vs. high is great than Con vs. low and low vs. high comparison. (b) Venn diagram showing separate and overlapping expression of DEGs when the control, low, and high groups are compared with each other. Each circle represents a group of gene sets, and the areas superimposed by different circles represent the intersection of these gene sets. (c) Heatmap expression of the top 50 upregulated and 50 downregulated DEGs which selected from Con vs. high, and the reads value of these genes in the 3 groups are displayed. (d) The 10 most significantly () enriched GO terms in the biological process branch are presented in three groups of comparisons. Con: control group; Low: low STZ treated group; High: high STZ treated group.

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