IL-6 Deficiency Attenuates Skeletal Muscle Atrophy by Inhibiting Mitochondrial ROS Production through the Upregulation of PGC-1α in Septic Mice

Figure 2

IL-6 KO attenuated CLP-induced skeletal muscle atrophy and weakness. (a) Immunoblots for Atrogin-1 and MuRF-1 in wild-type mice and IL-6 KO mice received sham operation or CLP; immunofluorescence staining (b) was performed to measure the CSA (c) of myofibers (green: anti-laminin was used to outline the myofibers); the maximum tetanic forces (d) and the force-frequency curves (e) were generated to evaluate muscle force-generating capacity. CLP: cecal ligation and puncture; CSA: cross-sectional area. , , and (ANOVA followed by unpaired Student -test, ).

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